What Exactly is Collagen?
Collagen is the most abundant protein in mammals. It is made up of three molecular chains, wound together in a tight triple helix. It mostly exists in the form of a fine fibre and is mainly found in the fibrous tissues such as the tendons, ligaments, cartilage, cornea, bones, blood vessels, intervertebral discs and the gut. The fibroblast is the most common cell which creates collagen.
The ‘tropocollagen’ or collagen molecule, is a sub-unit of larger collagen aggregates such as fibrils. It measures approximately 300 nanometers (nm) long and is 1.5nm in diameter, as a comparison a water molecule is only 0.278nm in diameter, hence collagen molecules are too large to penetrate the human skins outer layer in a lotion form, and are too large to be broken down by the stomach.
Revitalise collagen is produced from collagen-rich bovine hides which undergo enzymatic hydrolysis in order to break the collagen molecule down into smaller componeånts making it easier to digest which, in turn, permits quick intestinal absorption by the body.
Once the collagen hydrolysate is orally ingested, it pass through the stomach into the gastrointestinal tract. Here several enzymes from the pancreatic juices and the lining of the intestine, break it down to single amino acids and do-peptides. These smaller molecules, now in the small intestine (note that 95% of nutrient absorption takes place here), exist in a greater concentration than they do in the adjacent blood stream. Therefore , what is known as passive diffusion can occur, as the higher concentration gradient allows the collagen hydrolysate to pass through the cell membrane into the blood for transportation around the body.
What types of Collagen are there?
Up to now some 28 types of college have been identified throughout the body. The most predominant of which include:
Type one is the main component found in our bones. It is also found in our skin, vascular system, ligature, our tendons and our organs.
Type 2 Collagen is the main component found in Cartilage, the firm yet flexible connective tissue found in the larynx and respiratory tract, in structures such as the ear, and in the articulating surfaces of joints.
Collagen type 3 is the main component of reticular fibers – a type of fiber in connective tissue composed of type III collagen secreted by reticular cells. Reticular fibers crosslink to form a fine meshwork (reticulin). This network acts as a supporting mesh in soft tissues such as liver, bone marrow, and the tissues and organs of the lymphatic system.
Not only does Revitalise Collagen work with your body to replenish the collagen that is naturally produce, it stimulates your body helping to create collagen. The formulation contains both type One and Three collagen, with type Two being naturally produced by the body.
What are the Recommended Dosages?
The lowest maintenance dose we’d recommend to assist in general pain management is 1200mg (approx 3x 400mg capsules or 1 level teaspoon of powder) per day. This dosage is suitable for general aches and pains, anyone with long term chronic joint injury or those some 3 months on from a recovering soft tissue injury.
For competing professional athletes or sports men or women with a very severe injury and an extremely large height / body mass, we recommend 10G (approx 25 x 400g capsules or 5 teaspoons of powder) per day.
In reality for most people with a soft tissue or joint-based injury, whether in sport, undertaking physical work or struggling with arthritis and general joint aches and pains, the ideal dosage is around 4g per day for 6 weeks to 3 months and then follow this with the above recommended maintenance dose.
Collagen Hydrolysate contains no chemical additives and is widely considered by food agencies to be a safe food product for human consumption with no recorded maximum consumption amount. Suggested dosages are based on published research, undertaken by universities and refining company, and made available in the public domain. However, with these suggestions being based on currently available resources, if you are unsure always consult your doctor.
For more information, please see the Case Studies page.